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S. A. Keerthana ¹, V. Ramya ¹, Bagavad Gita ¹

Affiliations
1 Department of Periodontics, Sree Balaji Dental College and Hospital, IN

Abstract

Periodontitis is characterized by destruction of supporting structures of tooth and may also lead to loss of teeth if untreated. The aim of this review is to systematically evaluate the efficacy of 1% MF in the treatment of periodontitis. An electronic search was carried out using the keywords ‘metformin’,‘periodontal’ and ‘periodontitis’ via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 1949 toFebruary 2019.

Keywords

Metformin, Intrabony Defects, Periodontitis, Diabetes Mellitus.

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Bagavad Gita Jayaraman ¹, Nilofer Farjana ¹, S. A. Keerthana ¹

Affiliations
1 Sree Balaji Dental College and Hospital, BIHER, Chennai, IN

Abstract

Aim: To conduct a systematic review evaluating associations between periodontal disease and hypertension.

Method: A MEDLINE literature search of papers published between 2000 and March 2016 was conducted. Cross-sectional studies, prospective studies and nested case-control studies that studied the association between periodontitis and hypertension formed the mainstay of this literature review. This systematic review was conducted on the guidelines of the Cochrane Systematic Reviews and the conclusive evidence was based on the Canadian task force on preventive health care guidelines.

Results: A total of 21 articles were searched for relevancy, determined by article title, abstract and full copy, resulting in a yield of 17 studies that met our inclusion criteria. 1) There is a fair evidence (II-2 Grade B recommendation) for an association between chronic periodontitis and blood pressure with OR of 2.93 (95% CI:1.25-6.84) but the association becomes stronger when restricted with those with hypertension or taking anti-hypertensive medications: OR = 4.20(95% CI:1.28-13.80). 2) A good evidence (I, Grade A recommendation) that intensive periodontal therapy decrease cardiovascular risk scores (Framingham) at 296 mm (1.53% F 1.20% (95% CI 1.05-2.24, P = .0290) and 2.00% F 1.42% (95% CI 0.98-4.09, P = .0568).

Conclusions: With the available literature we conclude that,

1. There is a fair evidence for an association between chronic periodontitis and hypertension.

2. Intensive periodontal therapy reduces the systemic inflammatory markers and systolic blood pressure imminently at 6 months after the end of periodontal treatment.

Keywords

Chronic Periodontitis, Hypertension, Reactive Oxygen Species.

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Goutham Siriyala ¹, Nithya Anand ², Bagavad Gita ³, J. Bhaskar ², J. Bhuvaneswarri ⁴, S. A. Keerthana ¹

Affiliations
1 Post Graduate Student, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
2 Professor, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
3 Head of the Department, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
4 Reader, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN

Abstract

Background: Chronic kidney disease (CKD) is a veryreal and growing problem, as indicated by demographic trends. Presence of undiagnosed periodontitis may have significant effect on the medical management of CKD patient as its been found to contribute to systemic inflammatory burden.This study evaluate and compare the periodontal status and IL-6 levels among CKD, periodontitis and Healthy patients.

Materials and Method: Whole serum samples werecollected from 80 patients who were further divided into four groups; healthy (n=20), periodontitis (n=20), HD (n=20), PD (n=20). Serum IL-6 concentrations were determined by Standard enzyme -linked immunosorbent assay.

Results: Indicates the IL-6 levels in the studypopulation. The mean IL-6 value being highest in pre-dialysis (92.695) compared to dialysis (53.112), periodontitis (9.22) and healthy individuals (9.6). ANOVA results show a significant increase of IL-6 levels in the pre-dialysis group compared to alter groups. No significant change on PPD was appreciated.

Conclusion: Treatment of moderate to severeperiodontitis in ESRD populations will result in decreased IL-6 levels and, more importantly, decreased incidence of atherosclerotic complications awaits the result of interceptive clinical trials in this population

Keywords

Chronic Renal Disease, Periodontitis, Interleukin 6, End Stage Renal Disease, Dialysis, Periodontal Status.

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